She asked her friends if they would pose as her husband so that she could obtain a life insurance policy. She researched the effects of various poisons and how to obtain them discreetly. Andriano ordered poison and had it sent to a separate business.
Although Andriano claimed that she was physically and psychologically abused by her husband, none of her friends ever observed any signs of abuse.
Andriano began slipping sodium azide capsules to her husband. In the early morning hours of October 8, 2000, Andriano called 911 to report that her husband was having a heart attack, but when paramedics arrived, she turned them away.
Several hours later, she again called 911 to report that she had stabbed and beaten him in self-defense. When paramedics arrived, they found Joe Andriano dead from repeated beatings and a stab wound to the neck. Weak from the poisoning and chemotherapy, he was unable to defend himself against Andriano, who struck him at least 20 times with a bar stool before stabbing him in the neck.